Publications

2017

  1. Iljina, M., Hong, L., Horrocks, M.H., Ludtmann, M.H., Choi, M.L., Hughes, C.D., Ruggeri, F.S., Guilliams, T., Buell, A.K., Lee, J., Gandhi, S., Lee, S.F., Bryant, C.E., Vendruscolo, M., Knowles, T.P.J., Dobson, C,M., De Genst, E., Klenerman, D. Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species of ɑ-synuclein BMC Biology (Just Accepted).

  2. Janeczek, A.A., Scarpa, E., Horrocks, M.H., Tare, R.S., Rowland, C.A., Jenner, D., Newman, T.A., Oreffo, R.O.C., Lee, S.F., Evans, N.D., PEGylated liposomes associate with Wnt3A protein and expand putative stem cells in human bone marrow populations. Nanomedicine. (2017).

  3. Raynes, J.K., Crepin, P., Horrocks, M.H., Carver, J.A., Day L. Co-aggregation of κ-Casein and β-Lactoglobulin Produces Morphologically Distinct Amyloid Fibrils. Small. (2017).

2016

  1. Bongiovanni, M.N., Godet, J., Horrocks, M.H., Tosatto, L., Carr, A.R., Wirthensohn, D.C., Ranasinghe, R.T., Fritz, J.V., Dobson, C.M., Klenerman, D., Lee, S.F. Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping. Nat. Comm. (2016). (Joint first author).

  2. Broadhead M.J., Horrocks M.H., Zhu F., Muresan L.,Benavides-Piccione R., DeFelipe J., Fricker D., Kopanitsa M.V., Duncan R.R., Klenerman D., Komiyama N.H., Lee S.F., Grant S.G.N. PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits. Sci. Rep. (2016).

  3. Jönsson P., Southcombe J., Mafalda A., Santos A.M., Fernandes R.A., McColl J., Chang V.C., Godkin A., Dunne P.D., Horrocks M.H., Palayret M., Fugger L., Xu X., Davis S.J., Klenerman D.
    The remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions. PNAS (2016).

  4. Angelova, P., Ludtmann, M., Horrocks, M.H., Negoda, A., Cremades, N., Klenerman, D., Dobson, C.M., Wood, N., Pavlov, E., Gandhi, S., Abramov, A. Calcium is a key factor in alpha-synuclein induced neurotoxicity. J. Cell Sci. (2016). 

  5. Horrocks M. H., Lee S.F., Gandhi S., Magdalinou N.K., Chen S.W., Devine M.J., Toasatto, L., Kjaergaard M., Beckwith J.S., Zetterberg H., Iljina M., Cremades N., Dobson C.M., Wood N.W., Klenerman D. Single-molecule imaging of individual amyloid protein aggregates in human biofluids. ACS Chem Neurosci. (2016).

  6. Iljina,M., Garciaa, G.A., Horrocks, M.H., Tosatto, L., Choi, M.L., Ganzinger, K.A., Abramov, A.Y., Gandhi, S., Wood, N.W., Cremades, N.,Dobson, C.M. , Knowles, T.P.J., Klenerman, D. A kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading. PNAS. (2016).

2015

  1. Deas, E., Cremades, N., Angelova, P.R., Ludtmann, M., Yao, Z., Chen, S., Horrocks, M.H., Banushi, B., Little, D., Devine, M., Gissen P., Klenerman, D., Dobson, C.M., Wood, N., Gandhi, S., Abramov. A.Y. Alpha-synuclein oligomers interact with metal ions to induce oxidative stress and neuronal death in Parkinson’s disease. Antioxid. Redox Signal. (2015).

  2. Tosatto, L., Horrocks, M.H., Dear, A.J., Knowles, T.P.J., Dalla Serra, M., Dobson, C.M., Klenerman, D. Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants. Sci. Rep. (2015). (Joint first author)

  3. Reeve, A.K., Ludtmann, M.H.R, Angelova, P.R., Simcox, E.M., Horrocks, M.H., Klenerman, D., Gandhi, S., Turnbull, D.M., Abramov, A.Y. Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons. Cell Death and Disease. (2015).

  4. Horrocks, M.H., Tosatto, L., Dear, A.J., Garcia, G.A., Iljina, M., Cremades, N., Dalla Serra, M., Knowles, T.P.J., Dobson, C.M., Klenerman, D. Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of alpha-synuclein oligomers. Anal. Chem. (2015).

  5. Angelova, P.R., Horrocks, M.H., Klenerman D, Gandhi S, Abramov, A.Y., Shchepinov, M.S. Lipid peroxidation is essential for α-synuclein-induced cell death. J. Neurochem. (2015).

  6. Shammas, S. L., Garcia, G. A., Kumar S., A., Kjaergaard M., Horrocks, M.H., Shivji N., Mandelkow, E., Knowles T.P.J., Mandelkow E., Klenerman, D. A mechanistic model of tau amyloid aggregation based on direct observation of oligomers. Nat. Comm. (2015).

2014