Gratitude for a donation from Dr. Jim Love to aid our research

posted Mar 7, 2019, 12:24 AM by Mathew Horrocks   [ updated Mar 7, 2019, 12:42 AM ]

We are extremely grateful for the kind donation from Dr. Jim Love to the Edinburgh Single-Molecule Biophysics Group. The donation will partly be used to upgrade one of our microscopes to enable us to do live cell imaging of cultured neuronal cells. This added capability will greatly enhance the work that we can do in the group.

Dr. Jim Love received his Ph.D. from the School of Chemistry, University of Edinburgh, in 1963 under the supervision of Dr. Percival in the area of Carbohydrate Chemistry. Following this, he spent over 33 years with Dow Chemical in the USA, and retired in 1998 as Global Director of Discovery Process Research, Formulation Science and Technology in Agriculture.  


New group member

posted Mar 7, 2019, 12:16 AM by Mathew Horrocks   [ updated Mar 7, 2019, 12:17 AM ]

We're looking forward to Kelly Wood joining the ESMB in April. Kelly is part of the SOFI CDT scheme, and will be doing her PhD between our group and the Dynafluors group headed by Marc Vendrell in the QMRI. 

Mathew is running the London Marathon to support the Dementia Revolution

posted Jan 8, 2019, 1:17 AM by Mathew Horrocks

On April 28th, Mathew will be running the London Marathon to raise money for Alzheimer's Research UK, and the Alzheimer's Society. These charities provide support for vital research in neurodegenerative diseases, and each donation to them will bring us closer to fully understanding these disorders and generating a cure. Please sponsor Mathew:

https://uk.virginmoneygiving.com/MathewHHorrocks


Our latest paper used as a cover feature for ChemBioChem

posted Oct 7, 2018, 3:00 AM by Mathew Horrocks

Our latest work combining aptamers with DNA PAINT to generate super-resolution images of protein aggregates has featured as a cover feature for ChemBioChem. The cover was designed by Yukun Zuo (first author). 
http://dx.doi.org/10.1002/cbic.201800209

Welcome to new lab members

posted Oct 2, 2018, 5:36 AM by Mathew Horrocks   [ updated Oct 2, 2018, 5:36 AM ]

The Edinburgh Single-Molecule Biophysics group is pleased to welcome its newest members Alex Chappard, Owen Kantelberg, and Blair Hoggan. Alex and Owen have joined as Ph.D. students, and Blair is a fifth year undergraduate chemistry student. 

Research highlighted by the Dementia Revolution Blog

posted Jul 7, 2018, 2:16 AM by Mathew Horrocks

Read about our research on the Dementia Revolution Blog:
https://dementiarevolution.org/blog/blog-understanding-dementia-molecular-level

UK Korea Neuroscience Meeting

posted Jun 25, 2018, 6:44 AM by Mathew Horrocks

Mathew has been selected as a speaker at the 11th UK Korea Neuroscience meeting to be held in Busan, South Korea on 20-21st August. 

https://www.ukorea.ac.uk/events/11th-uk-korea-neuroscience-symposium-20th-21st-august-2018-haeundae-busan-korea/

Research from a UK-Australia collaboration published

posted Jun 25, 2018, 6:31 AM by Mathew Horrocks

Our work has recently been published in Cell Reports. The study makes use of single-molecule techniques to understand how extracellular molecular chaperones bind to aggregates formed from alpha-synuclein, the protein associated with Parkinson's disease. Usually, such aggregates have hydrophobic patches exposed, and it is believed that these enable them to punch holes into cell membranes, killing the cells. However, the chaperones bind to these patches, preventing them from damaging cells. As the body ages, it may be the case that these chaperones become less effective, and this could explain why neurodegenerative diseases become more prevalent with age. 

https://doi.org/10.1016/j.celrep.2018.05.074

New publication looking at the mechanisms of neuronal damage in Parkinson's disease

posted Jun 12, 2018, 2:07 AM by Mathew Horrocks

https://doi.org/10.1038/s41467-018-04422-2
There are many different species of alpha-synuclein, and it's therefore a challenge to know which one is a good biomarker or therapeutic target. Using highly resolved methods to study these at the nanoscale, we have helped demonstrate which form of alpha-synuclein is damaging to cells. To achieve this, we brought together a team from multiple disciplines, across different universities and a number of UK DRI centres. Harnessing the breakthroughs in single-molecule methods, single cell imaging and stem cell biology, we have been able to take a multifaceted approach to resolve a significant problem in neurodegeneration.

The study, published in Nature Communications, adds to our growing understanding of the causes of Parkinson’s and other neurodegenerative diseases, and could influence drug design in the future.

We found that in neurons, clumps of alpha-synuclein moved to and damaged key proteins on the surface of mitochondria - the energy powerhouses of cells - making them less efficient at generating energy. They also triggered a channel on the surface of mitochondria to open, causing them to swell and burst, leaking out chemicals that tell the cell to die.

These findings were replicated in human brain cells, generated from skin cells of patients with a mutation in the alpha-synuclein gene, which causes early-onset Parkinson’s disease. By turning patient skin cells into stem cells, we could chemically guide them into become brain cells that could be studied in the lab. This cutting-edge technique provides a valuable insight into the earliest stages of neurodegeneration - something that brain scans and post-mortem analysis cannot capture.

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