Continued support from Dr. Jim Love

posted Sep 17, 2019, 3:12 AM by Mathew Horrocks   [ updated Sep 17, 2019, 3:34 AM ]

We'd like to express our gratitude once again for the continued support from Dr. Jim Love. His financial support last time allowed us to build a single-molecule confocal microscope that is now being used to study the protein aggregates that are formed during the progression of Alzheimer's and Parkinson's disease. We will use this gift to further support our research, and in particular will use it to enhance our equipment within the laboratory. 


Jim received his Ph.D. from the School of Chemistry in 1963 under the supervision of Dr. Percival in the area of Carbohydrate Chemistry. Following this, he spent over 33 years with Dow Chemical in the USA, and retired in 1998 as Global Director of Discovery Process Research, Formulation Science and Technology in Agriculture.

Owen has been selected to give a talk at the MNDA International Symposium in Perth

posted Aug 30, 2019, 3:15 AM by Mathew Horrocks

We are looking forward to presenting our results at the MNDA symposium that's taking place in Perth (the Australian one) in December. Details can be found below:
https://symposium.mndassociation.org/

Well done to Alex and Owen for passing their first year vivas

posted Aug 30, 2019, 3:10 AM by Mathew Horrocks

After having a grilling from academics across the university, both Alex and Owen have now passed their first year vivas and are now officially PhD students. Both performed well under pressure, and impressed their examiners. Watch this space for their science making an appearance soon. 

Congratulations to Yiyun on completing her research project

posted Aug 30, 2019, 3:08 AM by Mathew Horrocks

Huge congratulations to Yiyun for completing her research project in the Edinburgh Single-Molecule Biophysics Group. Yiyun joined us for three months as part of her Master's degree in Medicinal Biochemistry, and worked on characterising a novel alpha-synuclein antibody using single-molecule confocal microscopy, fluorescence correlation spectroscopy, and TIRF microscopy. She recently presented her work at the School of Chemistry's student seminar day. 

Physical Chemistry at Firbush

posted Jun 7, 2019, 11:52 AM by Mathew Horrocks

The group had an amazing few days at the Physical Chemistry retreat at Firbush (Loch Tay). Lots of interesting science discussed in a relaxed environment. Topics ranged from "the worst mistakes in science", to "can dragons fly?", and "why are eggs fluorescent?". We also had great weather for the outdoor activities. 

 
 
 
 


Photonex conference

posted Jun 7, 2019, 11:41 AM by Mathew Horrocks   [ updated Jun 7, 2019, 11:42 AM ]

We had a great time at the Photonex conference finding out about the exciting research happening around Scotland at the moment. It was fantastic hearing our collaborators Brian Patton and Marti Colom present their research, and find out what Juan Varela from the Klenerman Group in Cambridge will be doing in his new role as a PI at St. Andrew's.

(Left to right: Alex, Owen Mathew, Craig, Kelly and Maggie).



The ESMB welcome Maggie (Yiyun Jin)

posted Jun 7, 2019, 11:37 AM by Mathew Horrocks

We are happy to welcome Maggie to our group for the summer. Maggie is a medicinal chemistry student, and will be working on a project looking at antibodies designed for lipid-binding proteins. 

ESMB complete the Edinburgh Marathon

posted Jun 7, 2019, 11:35 AM by Mathew Horrocks

On the 26th May, the ESMB team completed the Edinburgh Marathon in a time of 3h50. Alex took the first leg, completing 8.3 miles in an impressive 1h8m, he then had a short wait for Blair who was running to start his leg after having transport issues getting to the relay point. He did 5.5 miles in 1h2m (including getting to the transition). Mathew then did his 8 mile leg in 51m before handing over to Owen to bring home the glory by running 4.4 miles in 48m. 

Our work featured on the BBC!

posted Apr 17, 2019, 2:09 AM by Mathew Horrocks

Our work with Marc Vendrell on a range of new fluorophores for imaging metabolites has been featured on BBC news, and other media outlets. The work allows the metabolites that cells "eat" to be imaged, and could be used to differentiate between healthy, and cancerous cells. 

A new way of drug screening for Parkinson's disease

posted Apr 17, 2019, 2:05 AM by Mathew Horrocks

We're happy to have contributed to a new method for screening aggregation inhibitors for alpha-Synuclein, the protein associated with Parkinson's disease. The work was done in collaboration with Professor Manfred Auer's group in the School of Biology, and involves growing small protein aggregates on the surface of beads, which can then be imaged and analysed in an automated fashion. The paper was published in Analytical Chemistry.

http://dx.doi.org/10.1021/acs.analchem.8b03842


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